What Are Nootropics And How Do They Work?

Nootropics are sometimes referred to as “smart drugs”, “cognitive enhancers” or “brain supplements”, (in fact the word “Nootropic” originated in Greece, translates to “Towards the Mind”) In short, they are compounds that are both neurologically active and directly or indirectly enhances cognitive potential via increased capabilities. For example, reflexes, memory (both short and long term), energy, motivation, productivity, focus, mood lifts (states of wellbeing) and learning potential.

Romanian psychologist and chemist Dr. Corneliu E. Giurgea, the founding father of nootropics, was the first to attempt to define them. He developed six key criteria to qualify substances as true nootropics.

1. Enhancement of memory and learning

2. Improved cognition under stress

3. Protection of brain cells (neuroprotective)

4. Facilitation of cell-to-cell communication

5. Backed by human research demonstrating brain bioactivity

6. Absence of usual pharmacological effects of psychotropic drugs

A lot has changed since then, with the modern definition being any supplement that helps the brain in any way. This has created a large amount of supplements now categorized as Nootropics and the list is constantly growing. In fact, most people have been taking one of the most widely used Nootropics every day for decades. I’ll give you a hint… it’s in your morning cup of coffee. That’s right! Caffeine!

How Brain Boosting Supplements Work
There Are 6 Main Pathways In The Brain
That Are Enhanced By Nootropics.

Acetylcholine (ACh) – Memory, learning, and basic “thinking” cognition.

Dopamine (DA) – Mood and motivation; pleasure-reward pathway.

Gamma-Aminobutyric Acid (GABA) – “Downer” sedation and calmness; inhibits excessive excitation.

Norepinephrine (NE) – Attention and intense focus.

Epinephrine (EPI) – a.k.a. Adrenaline; intense energy.

Serotonin (5HT) – Relaxation and deep satisfaction.

An imbalance at any step – neurotransmitter synthesis, release, or uptake – may cause an imbalance across-the-board, resulting in disrupted emotions and cognition.

Nootropics may optimize neurotransmitters by:

  • Supplying brain chemical precursors
  • Promoting neurotransmitter synthesis
  • Enhancing receptor sensitivity
  • nhibiting neurotransmitter breakdown

The human brain is an intensely energy-demanding organ. It consumes about 20% of the body’s total energy reserves. There are two main reasons as to why your brain needs so much! (It’s a really needy organ)

  1. Maintenance – Neurons are in a constant state of death and genesis, growth, and injury, requiring high levels of energy to upkeep.
  2.  Management – Even healthy neurons require abundant energy to ensure they are properly signaling, receiving, and processing information.

If the body is unable to provide enough energy to the brain, or if the brain’s metabolic efficiency falters, then symptoms of brain fog and mental fatigue may surface. Furthermore, low brain energy levels are consistently linked to various states of cognitive decline and brain degeneration. This is where BrainRise comes in.

Nootropics may support brain energy by:

  • Enhancing metabolic activity of mitochondria, the powerhouses of brain cells (and other cells).
  • Helping to transport fatty acid material into brain cells, where they fuel mitochondria.
  • Increasing cerebral uptake of oxygen and nutrients, supplying the brain with “fuel” for energy production.

Brain Chemicals

Synaptic transmission, or cell-to-cell communication, occurs when one neuron transmits brain chemicals (neurotransmitters) to another neuron.
Think of neurotransmitters as “information” carriers: Depending on the type of information being transmitted, the receiving neuron may respond in any number of ways – yet ultimately transmits that particular message further to other adjacent brain cells, until the desired cognitive outcome is achieved.
Relevant neurotransmitter types and their respective associations in relation to cognitive performance include:
An optimized neurotransmitter status is one that bears not only a healthy reserve of each neurotransmitter but healthy neurotransmitter receptors, in addition to several other auxiliary factors – e.g., intrasynaptic enzymes.

An imbalance at any step – neurotransmitter synthesis, release, or uptake – may cause an imbalance across-the-board, resulting in disrupted emotions and cognition.

Nootropics may optimize neurotransmitters by:

  • Supplying brain chemical precursors
  • Promoting neurotransmitter synthesis
  • Enhancing receptor sensitivity
  • Inhibiting neurotransmitter breakdown

While there are numerous individual Nootropics to target almost any brain related task, the process of “stacking”, (which is the bringing together of multiple Nootropics that synergize well with each other and potentiate each other) creates the best results. It’s not easy to create the perfect stack as there is a lot of trial and error (especially if you don’t know what you are doing) and it can get expensive as well.This is why we created BrainRise, a perfectly tailored and meticulously formulated Nootropic stack to combat a large number of brain related issues at once.

What is Brain Rise ?

BrainRise is the culmination of a lot of hard work with experts in the nutraceutical field. It is a stack that was made with the common person in mind. Our best nootropic is a combination of 7 powerful brain enhancing ingredients that will improve your motivation, productivity, focus, energy, enhance creativity, help with your stress and enhance your overall cognitive processing. It is your productivity side-kick.

When creating a nootropic stack the main goal is to decide what you want from it overall and then set out to achieve it. We wanted to take the best brain boosting supplements, mood boosting supplements, the best supplements for mental clarity, and the overall best cognitive supplements, and use the best ingredients out of each (including some others that we weren’t finding in other similar nootropic stacks). The result was a blend of timeless natural ingredients and the best that modern day science has to offer. Then we found a way through a whole lot of research with top experts in the field, trial and error, and a lot of time, to create a blend that synergizes in the best possible way to make every ingredient harmonize with each other and be able to help the largest number of people possible.

With BrainRise you get the immediate benefit of cognitive enhancement to put you into the zone when you need it most and the long-term overall brain health. Our stack is a universal nootropic stack. Others on the market seek to only focus on one or two tasks in mind, but BrainRise reaches out to your entire brain to offer full optimization to promote a peak performance mental state.

What Does it Feel Like?

Upon taking BrainRise during periods of mental fatigue or brain-fog, or when you just don’t feel as sharp as you need to be, you’ll notice a very subtle mood-lift, enhanced energy, and before you even realize it, you’ll be locked into whatever given task you need to accomplish. BrainRise isn’t like being hit over the head with a hammer. You won’t start sweating and have your heart pounding out of your chest like a college kid after his 8th dose of Adderall.

Its effects will come to you often without you really noticing until you take a second to realize that you feel different, a sort of eureka moment of “Hey, I feel great! I don’t feel tired and lazy anymore, I feel lasered in!” It is a subtle but powerful effect and that’s how it was designed, to get you operating at your best version. BrainRise helps bring the flow state to you.


Vitamin B12 is essential for the synthesis of DNA, RNA and neurotransmitters, the maintenance of myelin sheaths protecting neurons, and red blood cell formation. Vitamin B12

Vitamin B12 (Cobalamin) helps:

  • Cerebral Circulation: Vitamin B12 is needed to regulate homocysteine. High homocysteine levels are linked to inflammation that can lead to blood vessel damage. And possible plaque buildup leading to heart attack or stroke.
  • Neurotransmitters: Vitamin B12 is a cofactor in the synthesis of neurotransmitters dopamine, GABA, norepinephrine, and serotonin. Affecting alertness, cognition, memory and mood.
  •  Mood: Vitamin B12 helps increase brain serotonin and dopamine levels. Decreasing anxiety, depression, fatigue and pain.

All of these very powerful ingredients mixed together with the right doses help boost the overall effect and créate a very unique Nootropic stack. The ingredients on their own do great things, but together, they can produce some real magic. That’s BrainRise.

L-Theanine can lower blood pressure, rejuvenate and relax you, boost your ability to think, improve focus and change your mood. L-Theanine balances brain chemistry and improves cognitive health.

L-Theanine helps: -Brain Waves. L-Theanine boosts alpha brain waves (8-12Hz) promoting alert relaxation and theta brain waves associated with creativity and relief from trauma.

  • Neurotransmitters: L-Theanine increases GABA, serotonin and dopamine levels in your brain. Producing an energizing and calming effect. And improving cognition and memory.
  • Neuroprotection: L-Theanine is an agonist of NMDA receptors and can inhibit synaptic release of glutamate. Protecting your brain from over-stimulation caused by glutamate, and possible glutamate toxicity.

Ashwagandha is commonly used to alleviate stress, anxiety, depression, and insomnia. It may also be beneficial for reducing blood sugar, cholesterol, and inflammation, as well as enhancing sleep, immunity, sports performance, memory, and brain function in both men and women. Additionally, ashwagandha may help improve male fertility and improve sexual dysfunction in females. Ashwagandha also appears to significantly lower the symptoms of stress and its associated disorders–like fatigue, insomnia, and cognitive impairment–and reduce cortisol levels in the blood. Human studies have associated ashwagandha supplementation with cortisol reductions ranging from 14.5 to 27.9% in stressed but otherwise healthy individuals, which is substantially greater than many other supplement

Bacopa Monnieri: Bacopa is an herbal supplement that balances levels of neurotransmitters and stress hormones, exerting a positive influence on mood, motivation, and memory. It’s highly prized as a brain tonic for reducing stress and anxiety, boosting mental energy and clarity, and protecting the brain from aging.

Bacopa can improve attention, memory, and the ability to learn in seniors, children, and everyone in between.

It can protect the brain from damage now, and from degenerative brain diseases later in life.

NOOPEPTIDE: Neurohackers use Noopept to boost cognition, energy, memory and learning. And to improve reflexes, perception, logical thinking and mood.

Noopept helps:

  • Brain Optimization: Noopept increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Critical for neuroplasticity and Long-Term Potentiation. Brain health gets a boost along with long-term memory.
  • Neuroprotection: Noopept prevents the release of excess glutamate in your brain. Glutamate is the brain’s primary excitatory neurotransmitter. When there’s a lack of oxygen in the brain, neurons can’t receive glutamate. This leads to toxic levels of glutamate within brain cells. And can result in neuron damage and death. Diminishing this neurotoxic overload with Noopept is potent neuroprotection.
  •  Brain Waves: Noopept boosts Alpha and Beta brain wave activity. You become calmer, notice a natural energy/mood lift, and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.

Sulbutamine: Sulbutiamine is simply two vitamin B1 molecules joined together. This chemical bond helps thiamine more easily cross the blood-brain barrier.

Sulbutiamine helps:

  •  Brain Optimization: Thiamine is critical for increasing focus, energy, creativity, and preventing memory loss. It can also ward off inflammation. Healthy brain function is crucial for good decision making.
  • Neurotransmitters: Thiamine is essential for producing the neurotransmitter acetylcholine (ACh). ACh is used to relay messages between neurons in your brain. And is critical for cognition, creative thought, and learning and memory.
  •  Mood: Thiamine helps your body withstand stress. A lack of energy can contribute to poor mood and motivation. Thiamine can boost your mood, and defend against depression and anxiety.

Alpha-GPC increases a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions. Alpha-GPC is used for Alzheimer disease, stroke, dementia caused by reduced blood flow to the brain (vascular dementia), memory and thinking skills, and other conditions.

Alpha GPC helps:

  • Brain Energy: Alpha GPC improves mood, and boosts mental energy. The extra choline can increase alertness and clarity of thought. It also synergizes very well with NooPept, helping to eliminate any possible minor side effects and acts as a potentiator as well.
  • Neurotransmitters: Alpha GPC is prized for its ability to improve memory. Its high bioavailability makes it a great source of choline for producing the neurotransmitter acetylcholine.
  • Brain Optimization: Alpha GPC boosts the development of new brain cells. And enhances your brain’s ability to repair damaged cell membranes.